WebNov 24, 2024 · A simple, room temperature approach for the fast single‐step synthesis of α‐phosphonyloxy ketone, a drug scaffold, has been developed which involves highly reactive species i.e., 1,2‐dicarbonyls that readily react with trialkyl phosphites and formic acids in batch as well as in continuous‐flow with the flow rate of 3 ml/min ( tR = ∼4 s). Web3-Ammonio-2-(phosphonyloxy)propane C3H10NO3P+2 CID 101624633 - structure, chemical names, physical and chemical properties, classification, patents, literature, …
1-Ammonio-2-(phosphonyloxy)pentane C5H14NO3P+2
WebThis generates α-phosphonyloxy enolates that are subsequently intercepted by aldehydes, leading to [1,4] O→O dialkoxyphosphinyl migration and finally to intramolecular ring closure. This protocol was used to synthesize a range of enantioenriched trans -α,β-epoxy imidates in moderate to high yields with excellent diastereoselectivities. WebBase-promoted addition of diethyl phosphite to α-ketoesters, followed by [1,2]-phosphonate/phosphate rearrangement, generates α-phosphonyloxy enolates that are … how do you charge a fusion core in fallout 4
Diethyl Phosphite-Initiated Coupling of α-Ketoesters with …
WebNov 1, 2024 · Request PDF Fast-Synthesis of α-Phosphonyloxy Ketones as Drug Scaffolds in a Capillary Microreactor A simple and room temperature approach for the fast … WebCoupling of α-ketoesters with imines initiated by diethyl phosphite in the presence of alkaline metal hexamethyldisilazides is reported. Base-promoted addition of diethyl phosphite to α-ketoesters, followed by [1,2]-phosphonate/phosphate rearrangement, generates α-phosphonyloxy enolates that are subsequently intercepted by imines. WebApr 15, 2024 · The two-step one-pot 1,6-conjugate addition provides effective access to a series of isatin-incorporated phosphate-bearing 1,6-adducts having two vicinal tertiary carbons with up to 90% yield and >20:1 dr . Publication types Research Support, Non-U.S. Gov't MeSH terms Benzoquinones Carboxylic Acids Indolequinones* Substances … how do you charge a cell phone wirelessly