Bongkrekic acid-13c28

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August undefined, 2024

WebDec 1, 2024 · Bongkrekic acid (BKA) inhibits adenine nucleotide translocator (ANT) and suppresses ADP/ATP exchange in the mitochondrial inner membrane. Previously, we … WebBongkrek acid (also known as bongkrekic acid) is a respiratory toxin produced in fermented coconut or corn contaminated by the bacterium Burkholderia gladioli pathovar …

Bongkrekic Acid - jbc.org

WebBongkrekic acid solution (Pseudomonas cocovenenans, >= 95% HPLC, ~ 1mg/mL); Bongkrekic acid solution has been used as an adenine nucleotide translocator (ANT) … Webthat bongkrekic acid is an inhibitor of oxidative phosphorylation in rat heart mitochondria, and that, unexpectedly, it also ac- celerated the oxidation of succinate and /3 … rotherham amateur dramatics

Bonqkrekic acid C28H38O7 - PubChem

WebFor example, bongkrekic acid, or exposure to uncouplers such as p -trifluoromethoxy carbonyl cyanide phenyl hydrazone (FCCP) to moderate Ca 2+ uptake during excitotoxicity, correspondingly moderate mitochondrial dysfunction and cell death in the short term. 105,106 However, by preventing mitochondrial adenylate exchange, and by uncoupling … WebBongkrekic acid (BKA) is an inhibitor of adenine nucleotide translocase (ANT). Since inhibition of ANT is connected to the inhibition of cytochrome c release from mitochondria, which then results in the suppression of apoptosis, it has been used as a tool for the mechanistic investigation of apoptosis. WebBongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the … rotherham alcohol licensing

Total synthesis of bongkrekic acid - American Chemical Society

The structure of bongkrekic acid - ScienceDirect

WebBongkrekic acid (BA) poisoning can be caused by eating spoiled or fermented foods contaminated with pseudomonas cocovenenans. Although some in vitro studies have … WebBongkrekic acid affects the liver, brain and kidneys, causing symptoms including lack of energy, dizziness, drowsiness, abdominal pain, vomiting etc. In severe cases, consuming food contaminated with Bongkrekic acid can be life threatening. What is SFA doing to reduce food safety risks from Bongkrekic Acid? st peter catholic church omaha nebraskaWebBongkrekic acid is a mitochondrial ANT toxin and is reported primarily in outbreaks of food-borne poisoning involving coconut and corn. It should be considered in outbreaks of food … st peter catholic church point pleasant nj

"WebThe inhibitors atractyloside and bongkrekic acid trap the AACs in two different conformations known as the c- and m-state where the carrier is open to the cytoplasmic … " - Bongkrekic acid-13c28

Bongkrekic acid-13c28

Bongkrekic acid solution - Sigma-Aldrich

WebMay 20, 1991 · Here we demonstrate that bongkrekic acid, a potent inhibitor of the mitochondrial ATP/ADP translocase, inhibits glucose-induced electrical activity in the pancreatic β-cell through the simulation of ATP-sensitive potassium channel (K-ATP-channel) activity. WebOct 1, 1982 · INTRODUCTION Bongkrek acid and toxoflavin are toxins which became well-known in connection with cases of food poisoning by the consumption of tempe bongkrek, one of the many fermented foods in Indonesia. It is made by fermentation of partially defatted coconut with Rhizopus oligosporus.

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WebBongkrekic acid (BA) is a sort of fatty acid produced by the bacterium Burkholderia gladioli pv. Cocovenenans, which survives in corn flour and coconut products (Travis M Falconer et al., 2016). First documented food poisoning case due to BA happened in Indonesia in 1895. WebDec 14, 2024 · This genus of fungi produces lipophilic and highly toxic 3-nitropropionic acid (3-NPA), which causes severe encephalopathy (disease of the brain that alters brain function or structure). This explained the symptoms in AC which were like those caused by bongkrekic acid.

WebOct 24, 2024 · Bongkrekic acid, produced by the bacterium, Burkholderia cocovenenans, is heat-stable and cannot be removed by washing. It has been implicated in outbreaks of foodborne illness involving... WebNov 22, 2004 · Bongkrekic acid (1) 1 is a natural toxic antibiotic produced by the microorganism Pseudomonas cocovenenans.The high toxicity of 1 has been attributed to its affinity for the ATP/ADP translocator protein residing in the mitochondrial inner membrane, which prevents oxidative phosphorylation (IC 50 = 2 × 10 −8 M). 2 Furthermore, by …

WebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. National Institutes of Health. Department of Health and Human Services. WebThe bongkrekic acid is produced by Pseudomonas cocovenenans on partially defatted coconutproducts. Though a submerged culture would make a larger production much easier, it appears that no bongkrekic acid is formed, if the partially defatted coconut-product is omitted. The strong antibiotic properties of bong-

WebMar 1, 1970 · The antibiotic bongkrekic acid is shown to inhibit the phosphorylation of added ADP coupled with either the reactions of the respiratory chain or the dismutation …

WebC 28 H 38 O 7. CAS number: 11076-19-0. EU number: Not assigned. Fermentek product code: BON. Source: Pseudomonas gladioli. st peter catholic church petersburg ilWebThe symptoms of 3-NPA toxicity in humans are similar to those for bongkrekic acid, as described regarding sugar cane poisoning in humans in China and Africa, including initial gastrointestinal symptoms with vomiting and diarrhea and progressing encephalopathy leading to coma and death (8,11,12). rotherham ambulance station addressWebJan 1, 2024 · Consumption of sufficient quantities of bongkrekic acid initially results in hyperglycemia, followed quickly by hypoglycemia that depletes the glycogen reserves in various tissues, including the heart and liver [5].A variety of symptoms are observed 4–6 h after consumption before lapsing into a coma, with death occurring 1–20 h after symptom … st peter catholic church reserve laWebJan 19, 2024 · Bongkrekic acid (BA), a little-known mitochondrial toxin produced by the bacterium Burkholderia gladioli pathovar (strain or set of strains with the same or similar … rotherham alternative provisionWebThe antibiotic bongkrekic acid is shown to inhibit the phosphorylation of added ADP coupled with either the reactions of the respiratory chain or the dismutation of α-ketoglutarate in mammalian mitochondria. It also prevents the utilization of ATP for energy-linked cation transport and in energy dissipation by uncoupling agents. However, … st peter catholic church reserve louisianaWebDec 21, 2024 · Bongkrekic acid (11076-19-0) is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT).1?Inhibits mitochondrial permeability transition pore opening.2,3?Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells.4 Uses rotherham allotmentsWeb米酵菌酸（Bongkrek acid、bongkrekic acid ）是發酵的椰子受唐菖蒲伯克氏菌污染，產生的呼吸毒素。米酵菌酸被認為可能是食用椰子製成的丹貝（於印度尼西亚禁止販售）之致 … st. peter catholic church quincy illinois